Page • Friday, October 22, 1999
World
Team unravels genetic coil
: Batta
John D. Huntley
Class of '79
31 3B South College Ave., College Station, TX 77840
(409) 846-8916
An authorized TAG Heuer dealer.
LONDON (AP) — An international team of
researchers said it is on the verge of unraveling
for the first time the genetic pattern of a human
chromosome — a milestone toward what ex
perts call one of the most important scientific
accomplishments ever.
The team, involving British, U.S. and Japan
ese scientists, is part of a worldwide collaboration
known as the Human Genome Project, which
aims to reveal the structure of the estimated
100,000 genes in human DNA.
That will help scientists better understand
what can go wrong in the body and how to fix it.
The group investigating chromosome 22 — the
second smallest of the 24 kinds of chromosomes
that carry human DNA — is putting the finishing
touches on its work and plans to submit it for pub
lication in the journal Nature later this year, team
leader Ian Dunham said yesterday.
“We have it completed now to the point where
there isn’t anything else we can do. We are now
working on the analysis,” Dunham, senior re
search fellow of the Sanger Center in Cambridge,
England, which is handling about a third of
the entire genome project, said.
Genes are arranged in tightly coiled
threads of DNA organized into pairs of
chromosomes in every cell of the body.
Genes can promote or cause disease
when they do not work properly. Some of
the illnesses linked to genes gone bad in
clude cancer, arthritis, diabetes, high
blood pressure, Alzheimer’s and multiple
sclerosis.
Chromosome 22 contains genes in
volved in the immune response, schizo
phrenia, heart defects, mental retardation,
leukemia and several other cancers, Bruce
Roe of the University of Oklahoma, part of
the team examining it, said.
The team, which also involves Keio
University in Japan, Washington Univer
sity in St. Louis and scores of labs across
the world, is revealing the sequence of
the building blocks of DNA along the
length of the chromosome.
) Decoding a human chromoso^
lo<
Researchers are poised to decipher the geneticpa'in
first human chromosome Here is a look at sontea
that map to regions on chromosome 22
GENE IN THE REGION
WHICH IS LINKED TO
Cat-Eye ayndrome
DiGeorgo syndrome
Mental retardation
Heart delects and merUT
Immunoglobulin light chain
Breakpoint cluster
Immune responsesysir.
Leukemia
S
nngioma deletion
Ewing't
Mentng
Bone cancer
Brain tumors
Neu rofibroblastoma
Cancer ot the nerves
ima deletion
Source UmversAy ot Oklahoma
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GROZNY, Russia (AP) — Salvos
of rockets slammed into a crowded
open air market and other parts of
Grozny, including a maternity hos
pital, yesterday, killing at least 118
people and injuring up to 400, a
Chechen official said.
Chechen officials said the rock
ets were fired by Russian forces
moving in on the capital. The Russ
ian Defense Ministry in Moscow
denied responsibility.
Bodies, severed body parts and
pools of blood were scattered
throughout the market after six rock
ets exploded in the stalls, which
were crowded with shoppers during
the early evening attack.
At least four other rockets
slammed into other parts of the city,
including one that hit a maternity
hospital, Magomed Magomadov, a
senior government official, said.
He said 118 people were killed
and between 300 people and 400
people were injured. Many of the
injured were in critical condition,
he said.
Russian forces moved in to
Chechnya in late September to im
pose a security zone around the
breakaway republic and to wipe out
Islamic militazits. Russian forces
were devastated by street fighting
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screaming and crying, ranforct
as the rockets exploded. Surroi
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pie trying to escape. Someonlool
tried to help the wounded.
“It was dark and then allofas
den, the place was illuminated
something was sparkling in the
Then we heard the explosion]
Umar Madayev said.
Grozny’s already overcroKfirougl
and poorly equipped hospitalsffilecoa
packed with the injured. A fewdKhts
tors, working with almost no inf ange
ications, operated on someofi
wounded under the glare
kerosene lamps because the el
tricity was out.
Badly wounded people lay
pools of blood in the dirty, darkci
ridors of the central hospital, will
there were no beds for them. [
Russian troops, meanwhile, dos
in on the Chechen capital, withal
vance tanks and armored pets®
carriers reportedly less than ei|
miles outside Grozny. Chechen ei
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cials said some Russian soldiers la- 0t lP es
been spotted even closer.
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