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Scientists link
schizophrenia
gene, nicotine
WASHINGTON (AP) — Scien
tists have located a gene that may
increase the risk of inheriting
schizophrenia — a finding that
could also explain why many
schizophrenics chain smoke.
Essentially, nicotine appears to
override briefly a brain defect
characteristic of the devastating
mental illness, providing frenzied
patients a few minutes of calm, re
searchers report in Tuesday’s edi
tion of Proceedings of the Nation
al Academy of Sciences.
“Schizophrenics are the most
heavy smokers of any psychotic pa
tients,” Dr. Robert Freedman of the
Denver Veterans Affairs Medical
Center said. “They had discovered
this (effect) before we had, and it
had been overlooked as a clue to the
biology of schizophrenia.”
At issue is the inability of many
schizophrenics to filter out unnec
essary sights, sounds and other
stimuli — that tapping tree branch
or the refrigerator hum that healthy
people can ignore — so they essen
tially suffer information overload.
Freedman and colleagues at
the University of Colorado discov
ered that this trait is inherited.
They linked a gene that appears
responsible for that to a brain re
ceptor which helps filter informa
tion, a receptor that can be stim
ulated by nicotine.
Schizophrenics who smoke
get enough nicotine to switch
on this receptor for brief relief,
Freedman said.
. “All the patients report they feel
great after a cigarette,” he said.
Gershon said while Freedman
has strong evidence linking this
schizophrenia trait to the nico
tine receptor gene, he does not
yet have proof. Freedman has
not found the gene mutation
that would cause it.
It is an important step forward
that points to a potential new target
for drug therapy, Gershon said.
“We certainly don’t recom
mend people take up smoking to
try to combat their schizophrenia
because the effect literally lasts
just a few minutes” and smoking
causes killer diseases like lung
cancer, he said.
The findings are “reassuring to
family members who wonder why
their (schizophrenic) children can’t
stop smoking,” he said.
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