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Page 2
The Battalion
Thursday, May 5, 1994
Huntington researcher backs gene therapy
By Rloise Flint
The Battalion
A leader of the research team that discovered
the gene that is responsible for Huntington’s Dis
ease told Texas A&M students she is currently
looking at ways to treat the disease.
The Texas A&M Health Science Center and the
University Lecture Series Committee cosponsored
the lecture “Clairvoyance and Caution: Repercus
sions from the Human Genome Project” Wednes
day night.
Dr. Nancy Wexler organized the Huntington’s
Disease Collaborative Research Group, a 58-mem-
ber team of researchers that discovered the defec
tive gene last year.
Wexler said they concentrated their research in
Venezuela, where the largest family of Hunting
ton’s sufferers reside.
Huntington’s Disease is an inherited condition
that affects two small areas of the brain that are
crucial in controlling body movements.
Those affected by the disease gradually lose
control of their muscles and eventually become
paralyzed.
“Huntington’s has a movement, cognitive and
emotional factor, in which you lose the ability to
think in sequence and logically,” Wexler said
“They recognize those people and things that are
important to them, but not everything.”
She said the disease has many other effects,
such as hallucinations, delusions, irritability and
depression.
“In the United States, one out of four Hunting
ton’s sufferers have made a suicide attempt,”
Wexler said.
It is difficult to determine a treatment because
when researchers come into contact with Hunting
ton’s sufferers, they are already very ill, she said.
“It is still too early because we don’t know what
the protein does,” Wexler said. “We hope the pro
tein will suggest the next step of treatment.”
She said there have been fashionable ideas
about antioxidant theories, and they hope to have
some idea for treatment in six months to a year.
The Huntington’s gene was discovered as a
replication on DNA.
“We now have to work on gene therapy and
presystematic testing,” Wexler said. “There is a
growing family of diseases and through testing we
will find more and more repeat diseases.”
Two major problems the research team have
encounterea when dealing with Huntington’s suf
ferers are discrimination and problems in gaining
insurance coverage.
“Privacy is poorly protected by state and federal
law,” Wexler said. “There is a bill in Congres
aimed at improving privacy of medical informa
tion, but the Dill is far from serving all purposes.”
Wexler said it is close to impossible to discuss
medical history with your doctor without it some
how being leaked to insurance companies.
“Once they find you have a preexisting condi
tion, they won’t insure you, or will only insure
certain things,” Wexler said. “If you have a histo
ry of colon or breast cancer, your insurance com
pany will insure you, but not your colon.”
Stew Milne/The Battalion
Dr. Nancy Wexler discusses Hunting
ton's disease at a lecture Wednesday at
Rudder Theater. Wexler promoted in
creased testing and gene therapy.
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