Tuesday, October 12,1993
The Battalion
Page 3
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JUST THE BEGINNING
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BOSTON - With the world
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CAMBRIDGE, Mass. — In 1977, two scientists
separately studying the virus that causes the com
mon cold discovered an unknown structure for
genes that revolutionized genetics and helped other
researchers earn a Nobel Prize.
On Monday, Phillip A. Sharp and Richard J.
Roberts won their own.
The Massachusetts-based scientists were named
co-recipients of the Nobel Prize in medicine and will
share an $825,000 prize.
"It felt good this morning, folks," Sharp said at a
news conference hours after his wake-up call from
the Nobel committee in Stockholm, Sweden.
"Everybody doing science wants to feel they are
going to make a discovery that everybody will look
up to," Roberts said at a separate news conference.
"But 1 think there's a different kind of satisfaction
that comes when you realize that all of your col
leagues also think it was a great discovery."
Sharp, 49, a native of Falmouth, Ky., heads the bi
ology department at the Massachusetts Institute of
Technology. Roberts, 50, a native of Derby, England,
works at New England Biolabs in Beverly, Mass.
Their work changed scientists' understanding
about DNA makeup and helped launch the field of
biotechnology.
Genes had been thought to be unbroken segments
along strands of DNA. Roberts and Sharp discovered
win Nobel Prize
that individual genes can also be discontinuous.
"Everybody thought that genes were laid out in
exactly the same way, and so it came as a tremen
dous surprise at the time," Roberts said in an inter
view.
The Nobel Assembly of the Karolinska Institute
said Sharp and Roberts' research "has been of funda
mental importance for today's basic research in biol
ogy, as well as for more medically oriented research
concerning the development of cancer and other dis
eases."
Scientists found that in humans and other higher
organisms, DNA includes separated gene segments
that contain information to build proteins along with
"nonsense DNA," or introns, that has no protein
message.
To construct working proteins from such gene
segments, cells have to assemble correctly the infor
mation from them. When this process goes awry, the
result can be cancer or other diseases.
Some scientists believe that the physical re
arrangement of gene segments may speed the evolu
tion of man and other higher animals.
Roberts said he "stumbled" upon the discovery.
"We were looking for something completely dif
ferent and things didn't quite work out the way we
expected, so we followed through to find out," he
said.
Sharp said he was "fortunate to be in the right
place at the right time doing the right experiment."
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