state
Protein fights off cancer
United Press International
HOUSTON — Medical re
searchers have successfully used
the natural protein, interferon,
in a year-long study to reduce
the size of tumors spread from
kidney cancers, but experts
warn “there’s still a long way to
g°-”
Dr. Jordan U. Gutterman of
the University of Texas’ M.D.
Anderson Hospital and Tumor
Institute said the significance of
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the development is that kidney
cancer and tumors that spread
from it have been very resistant
to treatment.
“It’s a continued advance,” he
said.
The interferon pioneer cal
led the development a small but
important step forward in use of
the substance, a protein found
in the body in tiny amounts.
He said treating cancers
spread from the kidneys is only a
first step in the eventual treat
ment of kidney cancer itself.
But, he cautioned, “There’s still
a long way to go.”
The results of Guttermap’s
year-long study conducted at
Anderson appear in the current
issue of Cancer Research, the
publication of the American
Association for Cancer Re
search.
“The importance of this study
is that (it appears) the use of a
relatively non-toxic biological
agent, interferon, can induce
disappearance of a metastatic
tumors (cancers that have
spread) in patients with a tumor
that previously was resistant to
other methods of treatment,”
Gutterman said.
Dr. Frank J. Rauscher Jr., re
search vice president of the
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American Cancer Society, said
studies by other investigators
already have supported Gutter-
man’s findings.
Kidney cancer usually is fatal
shortly after diagnosis. The can
cer society estimates this year
18,200 new cases of kidney and
urinary cancers other than blad-
“The importance of this
study is that (it appears)
the use of a relatively
n on - toxic biological
agen t, in terferon, ca n
induce disappearance
of a metastatic tumors
(cancers that have
spread) in patients with
a tumor that previously
was resistant to other
methds of treatment,”
Dr. Jordan U. Gutter-
man said.
der will be diagnosed, and 8,500
victims will die from the disease.
The Gutterman study in
volved 19 patients — 14 males
and five females — ranging in
age from 29 to 75 years old. All
suffered from malignant
tumors in their kidneys and in
each case the tumors had been
removed surgically.
Gutterman, along with Drs.
Jorge R. Quesada, David A.
Swanson and Antonio Trindale,
included in the study patients
whose kidney cancer had spread
to the lungs, the lymph nodes
behind the breasts or other parts
of the body.
To avoid contamination of
the results, all 19 patients were
removed from any other cancer
treatment a month before the
interferon test began.
The study showed that five of
the patients, or 26 percent,
showed a 50 percent or greater
decrease in the tumors in their
lungs after receiving daily inter
feron injections.
Two other patients, or 10.5
percent of the group, had be
tween 25 and 50 percent reduc
tion. Additionally, in one patient
the disease had stabilized for
over two months and in another
patient for six months.
In three other patients there
were mixed effects — both re
gression and progression of the
tumors in the same person’s
body. Seven patients, or 37 per
cent, showed progressive dis
ease during the study despite in
terferon.
Quesada said “follow-up has
been short to estimate the full
impact of this investigational
treatment on survival and clinic
al benefit to the patient.”
The study was supported by a
grant from the National Cancer
Institute, Enid Haupt Founda
tion, the Albert and Mary Las
ker Foundation and the Inter
feron Foundation, and coordin
ated by Dr. John Kirkwood, of
Yale Medical School.
The interferon was supplied
through the Interferon Founda
tion of Houston and the State
Serum Institute of the Finnish
Red Cross Center in Helskini,
Finland.
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